Adults in their early 60s, who spend less time sitting and more time engaged in light to vigorous physical activity, benefit with healthier levels of heart and vessel disease markers, according to new research published in the Journal of the American Heart Association, and the Open Access Journal of the American Heart Association/American Stroke Association.
The results from increased physical activity were found to be particularly good among women.
Physical inactivity is a well-known risk factor for cardiovascular disease and premature death from cardiovascular disease. Physical activity’s protective effect is likely due in part to its impact on biomarkers in the blood that help predict atherosclerosis risk.
"The 60 to 64 age range represents an important transition between work and retirement, when lifestyle behaviors tend to change," said Ahmed Elhakeem, Ph.D., study author and senior research associate in epidemiology at Bristol Medical School, University of Bristol. "It may, therefore, be an opportunity to promote increased physical activity.
"In addition, cardiovascular disease risk is higher in older adults. It’s important to understand how activity might influence risk in this age group," Elhakeem said. "We found it's important to replace time spent sedentary with any intensity level of activity."
Researchers studied more than 1,600 British volunteers, age 60 to 64, who wore heart rate and movement sensors for five days. The sensors revealed not only how much physical activity, in general, they were doing, but also how much light physical activity, such as slow walking, stretching, golfing or gardening, versus moderate-to-vigorous activity, such as brisk walking, bicycling, dancing, tennis, squash, lawn mowing or vacuuming.
Researchers analyzed participants’ blood levels for markers of cardiovascular disease, including inflammatory markers C-reactive protein and interleukin 6 (IL-6); endothelialmarkers, tissue-plasminogen activator (t-PA), the molecule E-Selectin (a cell adhesion molecule that plays an important part in inflammation); and cholesterol markers leptin and adiponectin.
"We focused on these atherosclerosis biomarkers as they are less studied and have been shown to predict risk of cardiovascular events and death," Elhakeem said.
Based on the study's findings, physical activity might lower cardiovascular disease risk by improving blood vessel function. Increased sedentary time may be adversely related to endothelial function, researchers said.
The study measured activity and biomarkers at the same time and didn’t establish whether activity influenced the biomarkers, or the biomarkers influenced activity, Elhakeem said.
To improve overall cardiovascular health, the American Heart Association suggests at least 150 minutes a week of moderate intensity or 75 minutes a week of vigorous-intensity aerobic physical activity (or a combination of the two) and muscle-strengthening exercises two or more days a week.
The UK Medical Research Council funded the study.
Article taken from University of Bristol.
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